Published: OctoIn cooperation with RNA binding proteins PUF and NOS, NCL-1 suppressed the translation Copyright: © 2015 Yi et al. Here, through a series of loss-of-function analyses, we Accepted: Septemreport that the nucleolar size is regulated by a circuitry composed of microRNA let-7, trans- lation repressor NCL-1, and a major nucleolar pre-rRNA processing protein FIB-1/fibrillarin. Caenorhabditis elegans provides a good model to address this question North Carolina at Chapel Hill, UNITED STATES owing to distinct tissue distribution of nucleolar sizes and a mutant, ncl-1, which exhibits Received: Jlarger nucleoli than wild-type worms. Copenhaver, The University of largely unknown. However, how metazoans control nucleolar size remains Editor: Gregory P. doi:10.1371/journal.pgen.1005580 with cell growth and development. PLoS Genet 11(10): Ribosome biogenesis takes place in the nucleolus, the size of which is often coordinated e1005580. Yi, Yung-Hsiang Ma, Tian-Hsiang Lee, Li-Wei Chiou, Pey-Tsyr Chen, Po-Hsiang Lee, Ching-Ming Chu, Yu-De Yu, Hsiang Hsiung, Kuei-Ching Tsai, Yi-Tzangħ-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans. A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis.
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